In the current study, the relationship between sources of STRESSors and COPING in the students of the University of Tehran and Medical Sciences University of Tehran has been investigated. This study aimed at finding information related to college students' COPING patterns, exploring sources of STRESSors for them, and their cognitive, affective, and behavioral responses to the STRESSful life events. In this study 1320 college students participated across different major fields, and data was gathered with utilization of three scales: STRESS Scale, STRESS Symptom Scale, and Adolescent COPING Scale. Findings showed a negative significant relation between COPING STYLES based on problem solving and STRESS symptom. In addition, the following STRESSors had significant roles in developing STRESS symptoms: Individuals habitual behaviors, academic events, marital problems, emotional-affective, social, and familial STRESSors. The unique features of this research were recognizing cognitive, behavioral, and affective domains of STRESS responses in college students. Applicability of these findings has been discussed thoroughly in the paper.